So it turns out that sexually transmitted infections today, most of them still respond to the treatments that we have always used. However, we are now starting to see the emergence of antibiotic resistance to some of the infections, which is very concerning. Gonorrhea in particular has over the last 10-15 years really been evolving in mutating such that our traditional treatments may not always work. Sometimes it will but sometimes we need to utilize additional antibiotics to make sure that we kill the infection. The other infection that's also been showing signs of antibiotic resistance is Trichomonas. Which is another, it's kind of like a bacterial infection that one can get through sex and it used to be that there was one antibiotic that would always a 100% kill the infection and now we are starting to see resistance to that antibiotic. And the unfortunate news is unlike Gonorrhea we don't have other medications that work against that infection. So we just have to go to higher doses or treat for longer periods of time and watch and wait, and hope that the infection will clear.