The first trimester blood tests have increased quite a bit over the last generation. There have been traditional blood tests given at the beginning of the first trimester which include blood type, blood count, tests for syphilis, hepatitis, HIV, thyroid, sometimes for liver functions. In recent times, there are more and more genetic screens that can be done including tests of Cystic Fibrosis, a condition call Fragile X Syndrome, sometimes some more specific tests in certain populations, like the Jewish population. In recent times, there has been the First Time Genetic Screen, which includes blood tests in addition to an ultrasound to detect markers for Down Syndrome, to determine who might need additional testing.