First of all, we don't really see, in childhood cancer, early detection is as big an issue as an adult cancer. The reason is that childhood cancer is tend to disseminate early. They tend to go other places in the body early on. So, it's very hard to really pick them up when they're very, very early in their course. Like you do with adult cancer. Which take a little longer to disseminate in general. But, there are some things that you can look at. If a child develops bruising, bleeding, looks anemic is having fevers, that sort of combination, usually means that there may be something wrong in the bone marrow. Where the blood is made. It may not be leukemia, maybe something else. But, certainly a group of symptoms together that one would say, "Well, I better take my child and have them looked." Certainly, if they develop an expanding lump, an expanding mass, either internally that's obvious to the family or externally, that's something that should be seen by a doctor. The other thing that I think are important are things like persistent nausea, vomiting and headache. Particularly, early morning. That's a sign of potentially a brain tumor. Again, not exclusively. And then someone who has persistent abdominal pain. To me, that deserves being looked at. It's not just pain one day, or couple of day. but persist. That deserves to be looked at to be sure there's not something is going on. Again, it may not be cancer. But, it's something that deserves to be looked at. And, it may turn out, in same cases, to be cancer.